A step forward to overcome the cytotoxicity of graphene oxide through decoration with tragacanth gum polysaccharide.

Mahdi Arefkhani, Amir Babaei, Maha Masoudi, Azade Kafashan

International journal of biological macromolecules 2023 Jan 31

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Hybridization of nanomaterials (NMs) with natural polymers is one of the best techniques to promote their exciting properties. In this way, the main objective of this work was to investigate the efficiency of decoration of the graphene oxide (GO) nano-sheets with tragacanth gum (TG) polysaccharide. To aim this, different approaches were used (with and without ultrasonic treatment) and various tests (XRD, FTIR, Raman, UV-Vis, DLS, Zeta potential, contact angle, AFM, FE-SEM, TEM, and MTT assay) were conducted. Test results indicated that the nano-hybrids were successfully synthesized. Furthermore, our findings represented that, the TG hybridized GO (TG-GO) appreciably enhanced the biocompatibility of GO. Moreover, it was demonstrated that the ultrasonic treatment of TG solution put a remarkable impact on the microstructure, wettability, and also surface charge characteristic of fabricated nano-hybrids and consequently improved the biocompatibility against L929-fibroblast cells. Copyright © 2022. Published by Elsevier B.V.

Citation

Mahdi Arefkhani, Amir Babaei, Maha Masoudi, Azade Kafashan. A step forward to overcome the cytotoxicity of graphene oxide through decoration with tragacanth gum polysaccharide. International journal of biological macromolecules. 2023 Jan 31;226:1411-1425