Low-grade B-cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition.

A 65-year-old woman with a resolved history of epilepsy due to a motor vehicle accident and hippocampal sclerosis presented with recurrent de novo seizures. Brain imaging demonstrated enhancement in the left parieto-occipital lobe. At histopathological examination, the lesion displayed a diffuse lymphoid infiltrate comprised of small atypical lymphocytes, plasmacytoid lymphocytes, and scattered plasma cells with amyloid deposition. Pathology workup demonstrated a monotypic B-cell phenotype of the lymphoid infiltrate, expressing lambda light chain restriction and plasmacytic differentiation without MYD88 mutations. The patient had no systemic evidence of lymphoma, plasma cell dyscrasia, or amyloidosis. A diagnosis of low-grade B-cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition was made. © 2022 Japanese Society of Neuropathology.

Citation

Gianluca Lopez, Karam Han, Shino D Magaki, Sophie X Song, Noriko Salamon, Kanwarpal S Kahlon, Inna Keselman, Ausaf A Bari, Harry V Vinters. Low-grade B-cell lymphoma of the central nervous system with plasmacytic differentiation and amyloid deposition. Neuropathology : official journal of the Japanese Society of Neuropathology. 2023 Aug;43(4):313-318

Mesh Tags

PMID: 36451532

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