Association of buccal micronucleus cytome assay (BMNCyt) biomarkers with inorganic element concentration and genetic polymorphisms in welders.

Environmental toxicology and pharmacology 2023 Jan

filter terms:

Welding fumes are classified as carcinogenic to humans. The aim of the present study was to measure buccal micronucleus cytome assay biomarkers and to evaluate their association with inorganic elements and genetic polymorphisms (XRCC1, OGG1, XRCC3, GSTM1, and GSTT1) in welders (n = 98) and control individuals (n = 100). Higher levels of DNA damage and cell death were observed in the exposed group. Also, a significant correlation between the frequency of micronuclei and Na, Si, Cl, Ti, Cr, Zn and Mg concentrations. The formation of micronuclei, binucleated cells, cell death was associated with polymorphisms in repair pathways. The OGG1Ser326Cys and XRCC3 241Thr/Met genotypes were associated with cell death. Individuals with GSTM1 null genotype had a higher frequency of micronuclei. These results demonstrate that the deleterious effects of exposure to welding fumes are exacerbated by lifestyle habits, and genetic polymorphisms can influence DNA damage and cell death. Copyright © 2022 Elsevier B.V. All rights reserved.

Citation

Milton Quintana-Sosa, Grethel León-Mejía, Diana M Narváez, Alejandra Suarez-Arnedo, Helena Groot de Restrepo, Yurina Sh De Moya, Martha Ruiz-Benitez, Karen Franco Valencia, Cristiano Trindade, Alvaro Miranda-Guevara, Johnny Dias, João Antonio Pêgas Henriques, Juliana da Silva. Association of buccal micronucleus cytome assay (BMNCyt) biomarkers with inorganic element concentration and genetic polymorphisms in welders. Environmental toxicology and pharmacology. 2023 Jan;97:104025