Effect of Angiotensin II Antagonism on Gastrointestinal Bleeding in Patients With Left Ventricular Assist Devices: A Systematic Review and Meta-Analysis.

Ahmad Mahmoud, Yasmeen Taha, Lauren E Meece, Anthony A Bavry, Mustafa M Ahmed

ASAIO journal (American Society for Artificial Internal Organs : 1992) 2022 Dec 01

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The importance of medical therapy to ameliorate the incidence and impact of left ventricular assistance device-related gastrointestinal bleeding has been highlighted recently with several single-center studies. Electronic databases were searched for studies that compared the incidence of gastrointestinal bleeding for those people on left ventricular assist support with and without angiotensin II inhibition. Angiotensin II inhibition was associated with a lower incidence of gastrointestinal bleeding (pooled RR 0.58, 95% confidence interval (CI): 0.34-0.98; p = 0.04], with a trend toward toward lower incidence with arteriovenous malformation-associated gastrointestinal bleeding (pooled RR 0.50, 95% CI: 0.25-1.03; p = 0.06). Copyright © ASAIO 2022.

Citation

Ahmad Mahmoud, Yasmeen Taha, Lauren E Meece, Anthony A Bavry, Mustafa M Ahmed. Effect of Angiotensin II Antagonism on Gastrointestinal Bleeding in Patients With Left Ventricular Assist Devices: A Systematic Review and Meta-Analysis. ASAIO journal (American Society for Artificial Internal Organs : 1992). 2022 Dec 01;68(12):1470-1474