Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B.

Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. Compound 2 displayed moderate antibacterial activities against Bacillus subtilis and Escherichia coli with MIC values of 25 and 12.5 μg/mL, respectively.

Citation

Zhao-Long Xu, Ben-Chao Li, Li-Li Huang, Liu-Xia Lv, Yan Luo, Wei-Feng Xu, Rui-Yun Yang. Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B. Natural product research. 2024 May;38(9):1503-1509

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PMID: 36469678

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