Expression of IRS2 in the female reproductive system during the estrous cycle in mice.

Zhongli Wang, Benyi Yi, Lijun Gan, Xiuli Li, Xiuxiu Liu, Qizhuang Lv, Lei Yang

Biotechnic & histochemistry : official publication of the Biological Stain Commission 2023 Apr

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Insulin receptor substrate 2 (IRS2) participates in reproduction; however, the location and expression of IRS2 in the reproductive system of female mice is not clear. We used real-time quantitative polymerase chain reaction (RT-PCR), western blot and immunohistochemical staining to investigate the expression of IRS2 in the ovary, oviduct and uterus of female mice during the estrous cycle. We found that IRS2 was expressed in all reproductive organs of mouse and that the expression level changed with the estrous phases. The expression of IRS2 in reproductive organs was greatest during estrus.

Citation

Zhongli Wang, Benyi Yi, Lijun Gan, Xiuli Li, Xiuxiu Liu, Qizhuang Lv, Lei Yang. Expression of IRS2 in the female reproductive system during the estrous cycle in mice. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2023 Apr;98(3):187-192