HIF1-α upregulation induces proinflammatory factors to boost host killing capacity after Aspergillus fumigatus exposure.

Huilin Su, Jiu Yi, Clement Km Tsui, Chunxiao Li, Junhao Zhu, Li Li, Qiangqiang Zhang, Yuanjie Zhu, Jinhua Xu, Min Zhu, Jiande Han

Future microbiology 2023 Jan

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Aims: HIF1-α is an important transcription factor in the regulation of the immune response. The protective function of HIF1-α in the host epithelial immune response to Aspergillus fumigatus requires further clarification. Methods: In this study we demonstrated the effect of upregulation of HIF1-α expression in A549 cells and mouse airway cells exposed to A. fumigatus in vivo. Results: The killing capacity was enhanced by boosting proinflammatory factors both in vitro and in vivo. Moreover, airway inflammation was reduced in the HIF1-α-upregulated mice. Conclusion: We identified a protective role for HIF1-α in anti-A. fumigatus immunity. Modulation of HIF1-α might be a target for the development of aspergillosis therapy.

Citation

Huilin Su, Jiu Yi, Clement Km Tsui, Chunxiao Li, Junhao Zhu, Li Li, Qiangqiang Zhang, Yuanjie Zhu, Jinhua Xu, Min Zhu, Jiande Han. HIF1-α upregulation induces proinflammatory factors to boost host killing capacity after Aspergillus fumigatus exposure. Future microbiology. 2023 Jan;18:27-41