Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Glycosylation of small molecules can significantly improve their physicochemical and biological properties. Only recently, decisive improvements in the biotechnological production of small-molecule glucosides (SMGs) have resulted in a large number of these compounds now being commercially available. In this study, we have analyzed a number of physical, chemical, and biological parameters of 31 SMGs, including solubility, stability, melting and pyrolysis points, partition coefficient log P, minimum inhibitory concentration against Escherichia coli (MIC), and enzymatic degradability. The properties such as water solubility, pH stability, and MICs of the glycosides were strongly dependent on the structures of the respective aglycones, which is why the SMG clustered according to their aglycones in most cases. Phenolic and furanone glucosides were readily hydrolyzed by saliva and skin microflora, whereas monoterpenol glycosides were poorer substrates for the enzymes involved. The results of this comparative analysis of SMGs provide valuable information for elucidating the biological functions of SMGs and the future technological applications of these useful natural products.


Fong-Chin Huang, Isabelle Effenberger, Thilo Fischer, Isabella-Louisa Hahn, Thomas Hoffmann, Wilfried Schwab. Comparative Physicochemical and Biochemical Characterization of Small-Molecule Glucosides. Journal of agricultural and food chemistry. 2022 Dec 21;70(50):15972-15980

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 36475669

View Full Text