Eudesmane-type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities.

Fifteen undescribed eudesmane-type sesquiterpenes, named atramacronoids D-R, along with fourteen known analogues were isolated from the rhizomes of Atractylodes macrocephala. The structures of atramacronoids D-R were elucidated based on extensive spectroscopic data analysis, Snatzke's rule, electronic circular dichroism (ECD) calculations, and X-ray crystallographic analysis. Notably, of the undescribed isolates, atramacronoids D and E are the first example of eudesmanolactam-phenol and eudesmanolactam-ethyl hybrids obtained from plants, respectively. A pair of enantiomers, (+)- and (-)-atramacronoids F, were successfully resolved by chiral-phase HPLC. Atramacronoid D exhibited weak cytotoxicity against SGC-7901 cells. Atramacronoid E significantly promoted the proliferation of LPS-induced IEC-6 cells. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Hai-Xin Zhang, Jin-Guang Si, Jing-Rong Li, Meng Yu, Ling-Ling Qin, Chen-Xu Zhao, Tao Zhang, Zhong-Mei Zou. Eudesmane-type sesquiterpenes from the rhizomes of Atractylodes macrocephala and their bioactivities. Phytochemistry. 2023 Feb;206:113545

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PMID: 36481315

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