Ilais Moreno Velásquez, Anders Malarstig, Damiano Baldassarre, Yan Borne, Ulf de Faire, Gunnar Engström, Per Eriksson, Philippe Giral, Steve E Humphries, Sudhir Kurl, Karin Leander, Lars Lind, Anders Lindén, Nicola Orsini, Matteo Pirro, Angela Silveira, Andries J Smit, Elena Tremoli, Fabrizio Veglia, Rona J Strawbridge, Bruna Gigante
Current research in translational medicine 2023 Jan-MarWe investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis. The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three independent studies and a meta-analysis was performed using a random model. In IMPROVE, each unit increase in plasma IL-8 was associated with an increase in median c-IMT measures (all p<0·03) in multivariable analyses. Linear regression identified rs117518778 and rs8057084 as associated with IL-8 levels and with measures of c-IMT. The two SNPs were combined in an IL-8-increasing genetic risk that showed causality of IL-8 on c-IMT in IMPROVE and in the UK Biobank (n = 22,179). The effect of IL-8 on c-IMT measures was confirmed in PIVUS (n = 1,016) and MDCCC (n = 6,103). The association of rs8057084 with c-IMT was confirmed in PIVUS and UK Biobank with a pooled estimate effect (β) of -0·006 with 95%CI (-0·008- -0·003). Our results indicate that genetic variants associated with plasma IL-8 also associate with c-IMT. However, we cannot infer causality of this association, as these variants lie outside of the IL8 locus. Copyright © 2022 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
Ilais Moreno Velásquez, Anders Malarstig, Damiano Baldassarre, Yan Borne, Ulf de Faire, Gunnar Engström, Per Eriksson, Philippe Giral, Steve E Humphries, Sudhir Kurl, Karin Leander, Lars Lind, Anders Lindén, Nicola Orsini, Matteo Pirro, Angela Silveira, Andries J Smit, Elena Tremoli, Fabrizio Veglia, Rona J Strawbridge, Bruna Gigante. Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis. Current research in translational medicine. 2023 Jan-Mar;71(1):103374
PMID: 36493747
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