Effect of valproate on sleep patterns disturbed by epilepsy.

Fructuoso Ayala-Guerrero, Daniel Castro-Domínguez, Erik L Mateos-Salgado, Graciela Mexicano-Medina, Carlos Alberto Gutiérrez-Chávez

Physiology & behavior 2023 Feb 01

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Nocturnal epilepsy is a neurological disease that has a significant effect on sleep. Various treatments have been implemented to help mitigate these effects and improve patients' quality of life. The use of experimental animal models for epilepsy has facilitated efficacy assessment and the development of different medications to treat the symptoms of this disease. The objective of this study was to evaluate the effect of valproate on sleep patterns altered by epilepsy. Chronically implanted Wistar rats were used to study sleep patterns over three consecutive days under different experimental conditions. The animals were separated into two groups. The first day was considered the control recording; on the second day, one group received pentylenetetrazol (PTZ) alone, and the other group received valproate prior to induction of convulsive seizures with PTZ administration. The results show that in addition to its antiepileptic effect, valproate has hypnotic properties. It is considered to facilitate the action of GABAergic mechanisms to mitigate the effect of convulsive seizures and increase the occurrence of sleep. Copyright © 2022. Published by Elsevier Inc.

Citation

Fructuoso Ayala-Guerrero, Daniel Castro-Domínguez, Erik L Mateos-Salgado, Graciela Mexicano-Medina, Carlos Alberto Gutiérrez-Chávez. Effect of valproate on sleep patterns disturbed by epilepsy. Physiology & behavior. 2023 Feb 01;259:114054