Inhibition of Lonp1 induces mitochondrial remodeling and autophagy suppression in cervical cancer cells.

Xiaona Wang, Xu Xu, Yu Zhao, Lifang Qi, Hongshan Ge

Acta histochemica 2023 Jan

filter terms:

Lon protease 1(Lonp1) is an ATP-dependent protease located in the mitochondrial matrix and plays a crucial role in preserving normal mitochondrial function. Lonp1 overexpression is associated with tumorigenesis in various cancer types, including cervical cancer. In the present study, we show that the Lonp1 content is elevated in cervical cancer tissues compared to cervical paracancerous tissues. Conversely, Lonp1 knockdown suppresses cervical cancer cell proliferation, migration and invasion but promotes apoptosis. Mechanistically, Lonp1 knockdown decreases area of mitochondrial networks and induces mitochondrial depolarization. Furthermore, Lonp1 inhibition reduces the level of LC3-II/I, PINK1 and Parkin, but promotes the level of p62. Collectively, our study suggests that the anti-cancer effect caused by Lonp1 downregulation likely contributes to mitochondrial remodeling and suppression of autophagy and mitophagy. Copyright © 2022 Elsevier GmbH. All rights reserved.

Citation

Xiaona Wang, Xu Xu, Yu Zhao, Lifang Qi, Hongshan Ge. Inhibition of Lonp1 induces mitochondrial remodeling and autophagy suppression in cervical cancer cells. Acta histochemica. 2023 Jan;125(1):151986