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The mitochondrial calcium uniporter (MCU) controls mitochondrial bioenergetics, and its activity varies greatly between tissues. Here, we highlight a recently identified MCU-EMRE-UCP1 complex, named thermoporter, in the adaptive thermogenesis of brown adipose tissue (BAT). The thermoporter enhances MCU activity to promote thermogenic metabolism, demonstrating a BAT-specific regulation for MCU activity. Copyright © 2022 Elsevier Ltd. All rights reserved.


Kaili Xue, Dongmei Wu, Yifu Qiu. Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity. Trends in cell biology. 2023 Mar;33(3):182-184

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PMID: 36517314

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