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Circular RNAs (circRNAs) are a novel class of non-coding RNAs and are conserved in various species. Although numerous circRNAs have been identified, their role in cancer remains unclear. The expression of circTMEM181 in 90 paired human hepatocellular carcinoma (HCC) and adjacent non-tumor (NT) tissues was detected using qRT-PCR. Transwell assay was performed for functional analysis of HCC cell migration and invasion. Luciferase reporter assay was used to verify the combination of circTMEM181 and miR-519a-5p. In this study, we identified a novel circular RNA, named circTMEM181, was downregulated in hepatocellular carcinoma (HCC) tissues. Decreased expression of circTMEM181 was associated with shorter overall survival of HCC patients. CircTMEM181 overexpression reduced HCC cell migration and invasion abilities, while circTMEM181 knockdown increased cell motility. Mechanically, circTMEM181 could directly bind to miR-519a-5p and subsequently upregulate ARHGAP29 protein expression. These data provide the first evidence of clinical significance and function of circTMEM181, and suggest the circTMEM181/miR-519a-5p/ARHGAP29 axis in HCC development. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.


Bing Chen, Qiaojuan Li, Yuchen Li, Qin Li, Hongyan Lai, Shenglin Huang, Caiping Li, Yan Li. circTMEM181 upregulates ARHGAP29 to inhibit hepatocellular carcinoma migration and invasion by sponging miR-519a-5p. Hepatology research : the official journal of the Japan Society of Hepatology. 2022 Dec 15

PMID: 36519254

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