PI(3,5)P2 and NAADP: Team players or lone warriors? - New insights into TPC activation modes.

Dawid Jaślan, Irene Flavia Ferro, Veronika Kudrina, Yu Yuan, Sandip Patel, Christian Grimm

Cell calcium 2023 Jan

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NAADP (nicotinic acid adenine dinucleotide phosphate) is a second messenger, releasing Ca2+ from acidic calcium stores such as endosomes and lysosomes. PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) is a phospho-inositide, residing on endolysosomal membranes and likewise releasing Ca2+ from endosomes and lysosomes. Both compounds have been shown to activate endolysosomal two-pore channels (TPCs) in mammalian cells. However, their effects on ion permeability as demonstrated specifically for TPC2 differ. While PI(3,5)P2 elicits predominantly Na+-selective currents, NAADP increases the Ca2+ permeability of the channel. What happens when both compounds are applied simultaneously was unclear until recently. Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.

Citation

Dawid Jaślan, Irene Flavia Ferro, Veronika Kudrina, Yu Yuan, Sandip Patel, Christian Grimm. PI(3,5)P2 and NAADP: Team players or lone warriors? - New insights into TPC activation modes. Cell calcium. 2023 Jan;109:102675