Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity.

Min-Kyung Nam, Hyun-Ah Shin, HeeJae Yun, Seung-Ah Yoo, Hyangshuk Rhim

Biochemical and biophysical research communications 2023 Jan 22

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The premature death and degeneration of striatal neurons are typical hallmarks of HtrA2-inactivated motor neuron degeneration 2 (mnd2) mice. Although HtrA2 has been extensively studied in relation to the regulation of apoptosis using mnd2 mice, little is known about the other physiological functions of HtrA2. In this study, we found that the skin color of wild-type (WT) and mnd2 mice was black and pink on postnatal day 32. Using histological and molecular assays (i.e., assessing the activation of MAPK and expression patterns of PCNA), we demonstrated that this differential skin color change is consistent with the delay in the telogen - to - anagen phase of the hair cycle in mnd2 mice. We also examined adipocytes in the subcutaneous skin layer, finding that HtrA2 inactivation leads to the growth retardation of adipocytes, thereby delaying the hair cycle of mnd2 mice. Collectively, these findings show for the first time that HtrA2 plays an essential role in regulating the adipogenesis-associated hair cycle. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Min-Kyung Nam, Hyun-Ah Shin, HeeJae Yun, Seung-Ah Yoo, Hyangshuk Rhim. Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity. Biochemical and biophysical research communications. 2023 Jan 22;641:102-109