Medicinal chemistry insights into antiviral peptidomimetics.

Dang Ding, Shujing Xu, Edeildo Ferreira da Silva-Júnior, Xinyong Liu, Peng Zhan

Drug discovery today 2023 Mar

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The (re)emergence of multidrug-resistant viruses and the emergence of new viruses highlight the urgent and ongoing need for new antiviral agents. The use of peptidomimetics as therapeutic drugs has often been associated with advantages, such as enhanced binding affinity, improved metabolic stability, and good bioavailability profiles. The development of novel antivirals is currently driven by strategies of converting peptides into peptidomimetic derivatives. In this review, we outline different structural modification design strategies for developing novel peptidomimetics as antivirals, involving N- or C-cap terminal structure modifications, pseudopeptides, amino acid modifications, inverse-peptides, cyclization, and molecular hybridization. We also present successful recent examples of peptidomimetic designs. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Dang Ding, Shujing Xu, Edeildo Ferreira da Silva-Júnior, Xinyong Liu, Peng Zhan. Medicinal chemistry insights into antiviral peptidomimetics. Drug discovery today. 2023 Mar;28(3):103468