Iron-catalyzed dual decarboxylative coupling of α-amino acids and dioxazolones under visible-light to access amide derivatives.

An iron-catalyzed decarboxylative C-N coupling of α-amino acids with dioxazolones is described herein to synthesize amide derivatives under visible-light. The desired products can be given in good to excellent yields under simple, mild, and oxidant-free conditions. This protocol provides a practical route for the transformation of α-amino acids to the corresponding amides. Computational studies were carried out to shed light on the mechanism of this reaction.

Citation

Zhanqun Liang, Kaifeng Wang, Qing Sun, Yuzhu Peng, Xiaoguang Bao. Iron-catalyzed dual decarboxylative coupling of α-amino acids and dioxazolones under visible-light to access amide derivatives. Chemical communications (Cambridge, England). 2023 Jan 17;59(6):752-755

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PMID: 36541573

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