Synthesis of dithioacetals via gold-catalysed hydrothiolation of vinyl sulfides.

Venkatesh Murugesh, Bokyeong Ryou, Cheol-Min Park

Organic & biomolecular chemistry 2023 Jan 18

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The synthesis of unsymmetrical dithioacetals based on gold catalysis is described. Although many approaches to the preparation of symmetrical dithioacetals have been developed, the methods to access unsymmetrical ones remain limited. In this regard, we report a mild synthetic method with a broad substrate scope. Screening of various gold catalysts identified a catalyst, which allows the hydrothiolation of both activated and unactivated vinyl sulfides with high efficiency. Moreover, the reaction displays broad compatibility for both aryl and aliphatic thiols.

Citation

Venkatesh Murugesh, Bokyeong Ryou, Cheol-Min Park. Synthesis of dithioacetals via gold-catalysed hydrothiolation of vinyl sulfides. Organic & biomolecular chemistry. 2023 Jan 18;21(3):585-589