Unmanned Aerial Vehicle Mediated Drug Delivery for First Aid.

Timely administration of key medications toward patients with sudden diseases is critical to saving lives. However, slow transport of first-aid therapeutics and the potential absence of trained people for drug usage can lead to severe injuries or even death. Herein, an unmanned aerial vehicle (UAV)-mediated first-aid system for targeted delivery (uFAST) is developed. It allows unattended administration of emergency therapeutics-loaded transdermal microneedle (MN) patches toward patients to relieve symptoms by a contact-triggered microneedle applicator (CTMA). The implementability and safety of the uFAST for first aid is demonstrated in a severe hypoglycemic pig model by automatically delivering a glucagon patch with immediate and bioresponsive dual release modes. This platform technique may facilitate the development of UAV-mediated first-aid treatments for other sudden diseases. © 2023 Wiley-VCH GmbH.

Citation

Tao Sheng, Rui Jin, Changwei Yang, Ke Qiu, Mingyang Wang, Jiaqi Shi, Jingyu Zhang, Yuman Gao, Qing Wu, Xin Zhou, Hao Wang, Juan Zhang, Qin Fang, Neng Pan, Yanan Xue, Yue Wang, Rong Xiong, Fei Gao, Yuqi Zhang, Haojian Lu, Jicheng Yu, Zhen Gu. Unmanned Aerial Vehicle Mediated Drug Delivery for First Aid. Advanced materials (Deerfield Beach, Fla.). 2023 Mar;35(10):e2208648

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PMID: 36563167

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