Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury.

Haotian Huanggu, Dan Yang, Yuehong Zheng

Autoimmunity reviews 2023 Mar

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Abdominal aortic aneurysm (AAA) occupies a large part of aorta aneurysm, and if there's no timely intervention or treatment, the risks of rupture and death would rise sharply. With the depth of research in AAA, more and more evidence showed correlations between AAA and autoimmune injury. Currently, a variety of bioactive peptides and cells have been confirmed to be related with AAA progression. Despite the tremendous progress, more than half researches were sampling from lesion tissues, which would be difficult to obtain. Given that the intrusiveness and convenience, serological test take advantages in initial diagnosis. Here we review blood biomarkers associated with autoimmune injury work in AAA evolution, aiming to make a profile on blood immune substances of AAA and provide a thought for potential clinical practice. Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Citation

Haotian Huanggu, Dan Yang, Yuehong Zheng. Blood immunological profile of abdominal aortic aneurysm based on autoimmune injury. Autoimmunity reviews. 2023 Mar;22(3):103258