Coagulopathy correlates with muscle titin injury in critically ill patients.

We hypothesized that coagulopathy independently contributes to muscle injury focusing to titin fragmentation, and investigated their correlations. We conducted a post-hoc analysis of an observational study, in which we evaluated muscle injury with the biomarker titin. Coagulopathy was assessed on the first day using the Japanese diagnostic criteria of acute-phase disseminated intravascular coagulopathy (JAAM-DIC). Mean N-titin/Cre measured on days 1, 3, 5, and 7 was assigned as the primary outcome. Overall, 111 eligible patients were included. Mean N-titin/Cre were significantly higher in the JAAM-DIC group. A multivariable analysis identified JAAM-DIC as independent risk factors for mean N-titin/Cre while other severity scores were not. Coagulopathy correlated with muscle titin fragmentation, as an independent risk factor. The present study is registered at the University Hospital Medical Information Network-clinical trials registry (UMIN000040290, Registration date: May 7, 2020). Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Kensuke Nakamura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Yasuhiro Ogawa, Yujiro Matsuishi, Nobutake Shimojo, Yoshiaki Inoue. Coagulopathy correlates with muscle titin injury in critically ill patients. Journal of critical care. 2023 Apr;74:154234

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PMID: 36565648

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