La-Catalyzed Decarbonylation of Formamides and Its Applications.

Herein we report the first catalytic decarbonylation and decarbonylative hydroamination of formamides without using additives enabled by a redox-neutral rare earth catalyst. The protocol displays complete N-aryl/alkenyl formamide-selectivity, thus providing a wide variety of creative uses of the N-formylation and N-deformylation method and opening up new prospects for minimizing waste and controlling the required selectivity in amine transformation events.

Citation

Shaocheng Li, Thayalan Rajeshkumar, Jincheng Liu, Laurent Maron, Xigeng Zhou. La-Catalyzed Decarbonylation of Formamides and Its Applications. Organic letters. 2023 Jan 13;25(1):163-168

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PMID: 36566387

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