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    The poor solubility, instability and low absorption rate obstruct the bioavailability of polyphenols isolated from Malus baccata (MBP) during gastrointestinal digestion. In order to solve the limitable problems, the food-grade nanoparticles were fabricated by mucin (MC) and Hohenbuehelia serotina polysaccharides (HSP) for delivery of MBP (MBP-NPs). The physicochemical properties and morphology of MBP-NPs prepared by different condition were respectively characterized. During gastrointestinal digestion in vitro, the release characteristic and variation in phenolic composition of MBP-NPs were evaluated. The results showed that MBP-NPs formed by hydrogen bonding and hydrophobic interaction possessed the regularly spherical shapes and smooth surfaces and semi-crystalline properties. Moreover, MBP-NPs presented the excellent physicochemical stability. During simulated gastrointestinal digestion in vitro, MBP-NPs exhibited the sustained release characteristics of phenolic compounds, which were confirmed by SDS-PAGE measurement. Compared with that of unencapsulated MBP, the significant variation was occurred in the phenolic composition of MBP-NPs, indicating that MBP-NPs could prevent the degradation and transformation of phenolic compounds. This study provides a novel strategy to improve the bioavailability of polyphenols. Copyright © 2022 Elsevier B.V. All rights reserved.


    Xiaoyu Li, Siying An, Cheng Wang, Qianyu Jiang, Dawei Gao, Lu Wang. Protein-polysaccharides based nanoparticles for loading with Malus baccata polyphenols and their digestibility in vitro. International journal of biological macromolecules. 2023 Feb 15;228:783-793

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    PMID: 36581037

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