A review: structure-activity relationship between saponins and cellular immunity.

Xuetao Cui, Xumin Ma, Chunhai Li, Hong Meng, Chunchao Han

Molecular biology reports 2023 Mar

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Saponins, which exhibit many different biological and pharmacological activities, are present in a wide range of plant species and in some marine organisms. Notably, the researchers have found that saponins can activate the immune system in mammals. The strength of this function is closely related to the chemical structure of saponins. The present study of the structure-activity relationship suggests that aglycones, glycochains on aglycones and special functional groups of saponins affect the immune activity of saponins. This paper reviews the effects of different saponins on cellular immunity. As well as the structure-activity relationship of saponins. It is hoped that the information integrated in this paper will provide readers with information on the effects of saponins on cellular immunity and promote the further study of these compounds. © 2022. The Author(s), under exclusive licence to Springer Nature B.V.

Citation

Xuetao Cui, Xumin Ma, Chunhai Li, Hong Meng, Chunchao Han. A review: structure-activity relationship between saponins and cellular immunity. Molecular biology reports. 2023 Mar;50(3):2779-2793