Dual-key-and-lock AIE probe for thiosulfate and Ag+ detection in mitochondria.

Junrong Li, Hong Huang, Chuang Zhang, Xulang Chen, Yanjun Hu, Xiaohuan Huang

Talanta 2023 Apr 01

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Ag+ ion detection has attracted much attention due to its important role in chemical and biological processes, as well as its potential threat to the environment and human health. Herein, we firstly constructed a dual-key-and-lock sensing strategy for Ag+ detection based on three-component co-assembly. An aggregation-induced emission luminogen (AIEgen), namely triphenylamine-thiophene-pyridinium (abbreviated to TPA-T-Py), showed unique co-assembly capability with Ag+ and S2O32- in PBS buffer (pH 7.4, 0.01 M). Cell imaging further proved that mitochondria can be lit up by TPA-T-Py under the dual key stimulation, which was successfully used for Ag+ and S2O32- detection in vitro. In brief, we provide a promising strategy for the construction of dual-lock imaging agents with organelle-targeting ability. Copyright © 2022 Elsevier B.V. All rights reserved.

Citation

Junrong Li, Hong Huang, Chuang Zhang, Xulang Chen, Yanjun Hu, Xiaohuan Huang. Dual-key-and-lock AIE probe for thiosulfate and Ag+ detection in mitochondria. Talanta. 2023 Apr 01;255:124222