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Microenvironment of cancer stem cells (CSCs) consists of a variety of cells and inter-cellular matrix and communications of the components. The microenvironment of CSCs maintains the stemness feature of the CSCs. Several cell types which communicate each other via signaling molecules surrounding CSCs are main factors of the CSC microenvironment. A key question is "What kind of information the cells exchange in the CSC microenvironment?" to reveal the microenvironment and CSC features. Components and molecular markers of CSC microenvironment, signaling cross-talks in CSC microenvironment, and targeting CSC microenvironment are focused in this review. © 2022. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.


Shihori Tanabe. Microenvironment of Cancer Stem Cells. Advances in experimental medicine and biology. 2022;1393:103-124

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PMID: 36587304

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