PROGNOSTIC POTENTIAL OF LYMPHOCYTE-TO-MONOCYTE RATIO AND CASPASE-8 IN PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEVELOPMENT.

The aim: To investigate the prognostic potential of lymphocyte-to-monocyte ratio and caspase-8 levels in prognosis of COPD development in healthy individuals. Materials and methods: 77 individuals were involved into the study: 47 with COPD and 30 healthy volunteers. Patients underwent examination according to GOLD 2022 Guidelines. Caspase-8 serum levels were measured by ELISA. Lymphocyte-to-monocyte ratio was calculated. Results: In crude and adjusted models lymphocyte-to-monocyte ratio and caspase-8 were associated with COPD development (respectively OR = 0.371 [95.0 % CI 0.217-0.634], p<0.006 and OR = 12.823 [95.0 % CI 2.104-78.134], p = 0.006). Additionally, systolic blood pressure had direct association with COPD (OR = 1.196 [95.0 % CI 1.028-1.391], p = 0.021). Noteworthy, diastolic blood pressure showed significant reverse association in univariate but not in multivariate analysis: OR = 0.850 [95.0 % CI 0.743-0.974] (p = 0.019) and OR = 0.820 [95.0 % CI 0.665-1.012] (p =0.064). Conclusions: Decreased lymphocyte-to-monocyte ratio and increased caspase-8 levels are important predictors of COPD development and can serve as an additional tool for early diagnosis of COPD in healthy individuals.

Citation

Volodymyr M Tverezovskyi, Valeriy A Kapustnyk, Borys O Shelest, Olga L Sadovenko. PROGNOSTIC POTENTIAL OF LYMPHOCYTE-TO-MONOCYTE RATIO AND CASPASE-8 IN PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE DEVELOPMENT. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2022;75(11 pt 1):2677-2682

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PMID: 36591753

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