Amiodarone-induced phlebitis: incidence and adherence to a clinical practice guideline.

Gunhild Brørs, Kari Hanne Gjeilo, Tonje Lund, Karin Skevik, Elizabeth Aa, Lise Husby Høvik, Torhild Skarsvaag, Ole Christian Mjølstad

European journal of cardiovascular nursing 2023 Dec 14

filter terms:

Intravenous amiodarone is an irritant of peripheral blood vessels with phlebitis as an adverse effect. The aims were to determine the incidence of intravenous amiodarone-induced phlebitis, to describe adherence to a clinical practice guideline, and to determine how characteristics were distributed between those with and without phlebitis. A prospective observational study was conducted. Adult patients treated with amiodarone through a peripheral intravenous catheter (PIVC) or a central venous catheter were included. PIVC characteristics were measured using the PIVC mini questionnaire. Patients with ≥two signs of phlebitis were categorized as having phlebitis. Adherence to the clinical practice guideline was registered on a standard abstract sheet. Data were collected from the amiodarone start-up to 2 days after the amiodarone was discontinued. In total, 124 patients with amiodarone infusions were observed, of which 69% were administered via a PIVC. The phlebitis rate was 44%. Fifty-three per cent developed amiodarone-induced phlebitis during the infusion phase, while 47% presented phlebitis during the post-infusion phase. The three most observed signs or symptoms of phlebitis were redness (87%), pain (81%), and swelling (71%). The most commonly used PIVC site was the elbow, and 35% of the PIVCs were large (18 gauge), which was the last preferred site and size according to the clinical practice guideline. A large proportion of the patients developed amiodarone-induced phlebitis. The adherence to the clinical practice guideline was not optimal according to the PIVC recommendations. Prevention of amiodarone-induced phlebitis should have high priority to reduce patient harm. © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.

Citation

Gunhild Brørs, Kari Hanne Gjeilo, Tonje Lund, Karin Skevik, Elizabeth Aa, Lise Husby Høvik, Torhild Skarsvaag, Ole Christian Mjølstad. Amiodarone-induced phlebitis: incidence and adherence to a clinical practice guideline. European journal of cardiovascular nursing. 2023 Dec 14;22(8):824-831