E S Pan, A V Pakhomova, N N Ermakova, S A Afanas'ev, Т Yu Rebrova, М А Zhukova, L А Sandrikina, О D Putrova, L V Kogai, О V Pershina, А М Dygai, Е G Skurikhin
Bulletin of experimental biology and medicine 2022 DecThe effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on young (3 months) and old (9 months) male Wistar rats with experimental liver cirrhosis. Ketanserin reduced inflammation, area of the connective tissue, and liver damage and improved serum biochemical parameters in rats of both age groups; in old rats, the effects were more pronounced than in young animals. In old rats, ketanserin reduced polarity of hepatocyte plasma and mitochondrial membranes in the area of protein-lipid contacts, which determined higher effectiveness of ketanserin during the treatment of liver cirrhosis in aged animals. © 2023. Springer Science+Business Media, LLC, part of Springer Nature.
E S Pan, A V Pakhomova, N N Ermakova, S A Afanas'ev, Т Yu Rebrova, М А Zhukova, L А Sandrikina, О D Putrova, L V Kogai, О V Pershina, А М Dygai, Е G Skurikhin. Age-Related Features of Ketanserin Effects in Experimental Liver Cirrhosis. Bulletin of experimental biology and medicine. 2022 Dec;174(2):205-209
PMID: 36600039
View Full Text