Carotenoids production and genome analysis of a novel carotenoid producing Rhodococcus aetherivorans N1.

Wankui Jiang, Jingxiang Sun, Haiyan Gao, Yunhan Tang, Chao Wang, Yujia Jiang, Wenming Zhang, Fengxue Xin, Min Jiang

Enzyme and microbial technology 2023 Mar

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Carotenoids are a series of natural pigments with unique structure and physiological functions. In this study, a novel Rhodococcus aetherivorans strain N1 was discovered, which can produce 6.4 mg/g carotenoids including β-carotene, zeaxanthin and isorenieratene from glucose. Moreover, strain N1 can directly produce 3.0 mg/g carotenoids from the undetoxified straw hydrolysate, representing the highest carotenoids production from the undetoxified lignocellulosic hydrolysate. The crude carotenoid extracts of strain N1 showed efficient free radical scavenging activity and stability. Strain N1 has complete methylerythritol 4-phosphate (MEP) pathway and related genes for carotenoid synthesis, especially the rare aromatic carotenoid of isorenieratene. Genomic comparison between strain N1 and other carotenoid producing Rhodococcus sp. strains showed the conservatism and universality of carotenoids synthesis gene. These results proved that R. aetherivorans strain N1 can serve as a promising producer for the industrialization of carotenoid production. Copyright © 2023 Elsevier Inc. All rights reserved.

Citation

Wankui Jiang, Jingxiang Sun, Haiyan Gao, Yunhan Tang, Chao Wang, Yujia Jiang, Wenming Zhang, Fengxue Xin, Min Jiang. Carotenoids production and genome analysis of a novel carotenoid producing Rhodococcus aetherivorans N1. Enzyme and microbial technology. 2023 Mar;164:110190