Tumor-promoting roles of HMMR in lung adenocarcinoma.

Qihao Wang, Guomin Wu, Linhai Fu, Zhupeng Li, Yuanlin Wu, Ting Zhu, Guangmao Yu

Mutation research 2023 Jan-Jun

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Searching for differential genes in lung adenocarcinoma (LUAD) is vital for research. Hyaluronan mediated motility receptor (HMMR) promotes malignant progression of cancer patients. However, the molecular regulators of HMMR-mediated LUAD onset are unknown. This work aimed to study the relevance of HMMR to proliferation, migration and invasion of LUAD cells. Let-7c-5p and HMMR levels in LUAD cells and HLF-a cells were assessed, and their correlation was also detected. Their interaction was determined by dual-luciferase experiments and qRT-PCR. Cell proliferation, migration and invasion potentials in vitro were validated through cell counting kit-8 (CCK-8), colony formation, scratch healing, and transwell assays. The expression of HMMR was examined by qRT-PCR and western blot and the expression of let-7c-5p was assayed by qRT-PCR. It was found that HMMR level was increased in LUAD and negatively correlated with let-7c-5p level. Let-7c-5p directly targeted HMMR to repress LUAD cell proliferation, migration and invasion. The above data illustrated that the let-7c-5p/HMMR axis may provide certain therapeutic value for LUAD patients. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Qihao Wang, Guomin Wu, Linhai Fu, Zhupeng Li, Yuanlin Wu, Ting Zhu, Guangmao Yu. Tumor-promoting roles of HMMR in lung adenocarcinoma. Mutation research. 2023 Jan-Jun;826:111811