IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice.

Dongming Guo, Yang Xu, Zhenghai Liu, Yingge Wang, Xiaofan Xu, Cai Li, Suyun Li, Jingwen Zhang, Tianqing Xiong, WenYu Cao, Jingyan Liang

Brain research bulletin 2023 Mar

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Over-activated microglia and inflammatory mediators are found in patients with depression, while manipulation of the microglia function might represent a potential therapeutic strategy. Insulin-like growth factor 2 (IGF2) has been implicated in bacterial infections and autoimmune disorders, but the role of IGF2 on the active phenotype of microglia and neuroinflammation has not been well established. IGF2 influences in modulating microglia responding to neuroinflammation induced by lipopolysaccharide（LPS）challenge will be carefully examined. In the current study, we verified that systemic IGF2 treatment could produce an anti-depression effect in LPS-treated mice. Particularly, we found that systemic IGF2 treatment inhibited microglia over-activation and prevented its transformation to a pro-inflammatory phenotype, thereby protecting hippocampal neurogenesis. Since microglia reactive to neuroinflammation is a common feature of neuropsychiatric disorders, the discoveries from the present study may provide therapeutic innovation for these diseases. Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Dongming Guo, Yang Xu, Zhenghai Liu, Yingge Wang, Xiaofan Xu, Cai Li, Suyun Li, Jingwen Zhang, Tianqing Xiong, WenYu Cao, Jingyan Liang. IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice. Brain research bulletin. 2023 Mar;194:1-12