Water-soluble NHC Pd/Ni bimetallic nanoparticles for H/D exchange in aromatic amino-acids.

Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an enantiospecific fashion without reducing the aromatic ring of phenylalanine and tyrosine thanks to a synergetic Pd-Ni effect.

Citation

Oscar Suárez-Riaño, Gabriel Mencia, Simon Tricard, Jerome Esvan, Pier-Francesco Fazzini, Bruno Chaudret, Edwin A Baquero. Water-soluble NHC Pd/Ni bimetallic nanoparticles for H/D exchange in aromatic amino-acids. Chemical communications (Cambridge, England). 2023 Jan 24;59(8):1062-1065

Mesh Tags

Substances

PMID: 36606591

search → result