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    Topical tretinoin has historically been limited by poor tolerability and molecular instability. Research advances have enhanced its efficacy and tolerability, along with reducing oxidation and photodegradation. By overcoming historical limitations, tretinoin use can be extended to patient populations and clinical situations previously not suitable. This review discusses historical limitations of tretinoin, methods employed to overcome those limitations, use within clinical practice, and new formulations of tretinoin for the treatment of acne. J Drugs Dermatol. 2023;22(1):35-40. doi:10.36849/JDD.7146.


    Hilary Baldwin, Omar Noor, J Jackson, James Leyden, Maya Erlich, Rajeev Chavda, Krysten Arekapudi, Guy Webster. Tretinoin Review With Newer Formulations: Providing Effective and Tolerable Solutions in Clinical Practice. Journal of drugs in dermatology : JDD. 2023 Jan 01;22(1):35-40

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    PMID: 36607761

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