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The mechanistic target of rapamycin complex 1 (mTORC1) senses cellular leucine levels through the GATOR1/2-Rag axis. Jiang et al. show that the Ring domains of GATOR2 subunits maintain the integrity of the complex and promote ubiquitination and inhibition of GATOR1, thereby leading to mTORC1 activation. Copyright © 2022 Elsevier Inc. All rights reserved.


Umakant Sahu, Issam Ben-Sahra. GATOR2 rings GATOR1 to speak to mTORC1. Molecular cell. 2023 Jan 05;83(1):6-8

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PMID: 36608671

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