Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader IGF2BP2 in leukemia-initiating cells, illuminating exciting new therapeutic targets for leukemia. Copyright © 2022 Elsevier Inc. All rights reserved.
Takeshi Fujino, Omar Abdel-Wahab. New readers and writers of RNA modifications unique to leukemia stem cells. Cell stem cell. 2023 Jan 05;30(1):3-4
PMID: 36608677
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