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In eukaryotic cells, the budding and fusion of intracellular transport vesicles is carefully orchestrated in space and time. Locally, a vesicle's source compartment, its cargo, and its destination compartment are controlled by dynamic multi-protein specificity modules. Globally, vesicle constituents must be recycled to ensure homeostasis of compartment compositions. The emergence of a novel vesicle pathway therefore requires new specificity modules as well as new recycling routes. Here, we review recent research on local (molecular) constraints on gene module duplication and global (cellular) constraints on intracellular recycling. By studying the evolution of vesicle traffic, we may discover general principles of how complex traits arise via multiple intermediate steps. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.


Mukund Thattai. Molecular and cellular constraints on vesicle traffic evolution. Current opinion in cell biology. 2023 Feb;80:102151

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PMID: 36610080

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