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p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein. See related article by Guiley and Shokat, p. 56 (3). ©2023 American Association for Cancer Research.
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David P Lane, Chandra S Verma. Covalent Rescue of Mutant p53. Cancer discovery. 2023 Jan 09;13(1):14-16
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PMID: 36620883
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