Microbiota and hepatitis C virus in the era of direct-acting antiviral agents.

Biagio Pinchera, Nicola Schiano Moriello, Antonio Riccardo Buonomo, Emanuela Zappulo, Giulio Viceconte, Riccardo Villari, Ivan Gentile

Microbial pathogenesis 2023 Feb

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The gut microbiota plays a fundamental role in Hepatitis C Virus (HCV)-related liver disease. Indeed, HCV infection alters the gut microbiota, whereas intestinal dysbiosis induces an underlying inflammatory state. This status may lead to liver disease progression. The advent of direct acting antivirals (DAAs) was a turning point in the history of HCV infection, which enhances the chances of recovery. Beyond the elimination of the virus, DAA therapy can affect the gut microbiota of the HCV patient. The study of the gut microbiota in the patient with HCV-related liver disease could be the first step in understanding the etiopathogenesis of hepatopathy thereby opening the way to new therapeutic opportunities. Herein we evaluate current knowledge regarding the gut microbiota in patients with HCV infection and the impact of DAA therapy. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Biagio Pinchera, Nicola Schiano Moriello, Antonio Riccardo Buonomo, Emanuela Zappulo, Giulio Viceconte, Riccardo Villari, Ivan Gentile. Microbiota and hepatitis C virus in the era of direct-acting antiviral agents. Microbial pathogenesis. 2023 Feb;175:105968