Sulfathiazole treats type 2 diabetes by restoring metabolism through activating CYP19A1.

Zhuozhou Hu, Chun Li, Tongyu Wu, Jing Zhou, Liang Han, Jingjing Liu, Shaojia Qiang, Wenyang Zhao, Xiangxiang Li, Xiaohua Liu, Jiazhong Li, Xinping Chen

Biochimica et biophysica acta. General subjects 2023 Mar

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Globally, diabetes mellitus has been a major epidemic bringing metabolic and endocrine disorders. Currently, 1 in 11 adults suffers from diabetes mellitus, among the patients >90% contract type 2 diabetes mellitus (T2DM). Therefore, it is urgent to develop new drugs that effectively prevent and treat type 2 diabetes through new targets. With high-throughput screening, we found that sulfathiazole decreased the blood glucose and improved glucose metabolism in T2DM mice. Notably, we discovered that sulfathiazole treated T2DM by activating CYP19A1 protein to synthesize estrogen. Collectively, sulfathiazole along with CYP19A1 target bring new promise for the better therapy of T2DM. Copyright © 2023 Elsevier B.V. All rights reserved.

Citation

Zhuozhou Hu, Chun Li, Tongyu Wu, Jing Zhou, Liang Han, Jingjing Liu, Shaojia Qiang, Wenyang Zhao, Xiangxiang Li, Xiaohua Liu, Jiazhong Li, Xinping Chen. Sulfathiazole treats type 2 diabetes by restoring metabolism through activating CYP19A1. Biochimica et biophysica acta. General subjects. 2023 Mar;1867(3):130303