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How gut regionalization impacts microbiota and immunity is unclear. In this issue of Immunity, Earley et al. show that jejumal GATA4 expression controls bacteria colonization through retinol metabolism and IgA production. This metabolic-immune axis limits intestinal Th17 responses and immunopathology. Copyright © 2022 Elsevier Inc. All rights reserved.
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Licia Torres, Ana M C Faria. GATA4 as a maestro of gut regionalization. Immunity. 2023 Jan 10;56(1):1-3
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PMID: 36630909
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