Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.

Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples' HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk. © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Citation

Yunqi Li, Francois Lefebvre, Edith Nakku-Joloba, Allan Ronald, Glenda Gray, Guy de Bruyn, James Kiarie, Connie Celum, Mark J Cameron, Jairam R Lingappa, Romel D Mackelprang. Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection. The Journal of infectious diseases. 2023 Jan 13;227(5):714-719

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PMID: 36637125

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