The Integrator complex desensitizes cellular response to TGF-β/BMP signaling.

Maintenance of stem cells requires the concerted actions of niche-derived signals and stem cell-intrinsic factors. Although Decapentaplegic (Dpp), a Drosophila bone morphogenetic protein (BMP) molecule, can act as a long-range morphogen, its function is spatially limited to the germline stem cell niche in the germarium. We show here that Integrator, a complex known to be involved in RNA polymerase II (RNAPII)-mediated transcriptional regulation in the nucleus, promotes germline differentiation by restricting niche-derived Dpp/BMP activity in the cytoplasm. Further results show that Integrator works in various developmental contexts to desensitize the cellular response to Dpp/BMP signaling during Drosophila development. Mechanistically, our results show that Integrator forms a multi-subunit complex with the type I receptor Thickveins (Tkv) and other Dpp/BMP signaling components and acts in a negative feedback loop to promote Tkv turnover independent of its transcriptional activity. Similarly, human Integrator subunits bind transforming growth factor β (TGF-β)/BMP signaling components and antagonize their activity, suggesting a conserved role of Integrator across metazoans. Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Citation

Sen Liu, Gyeong Hun Baeg, Ying Yang, Feng Guang Goh, Hongcun Bao, Eric J Wagner, Xiaohang Yang, Yu Cai. The Integrator complex desensitizes cellular response to TGF-β/BMP signaling. Cell reports. 2023 Jan 31;42(1):112007

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PMID: 36641752

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