Acquired alpha-thalassemia in an 86-year-old patient with myelodysplastic syndrome].

D Cortese, C Martinez, A Dindoyal, I Alamome, R Dragan, J Chapiro, G Blaison, O Hinschberger

La Revue de medecine interne 2023 Feb

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Alpha thalassemia-myelodysplastic syndrome (ATMDS) is one of the possible complications related to the genetic instability typical of clonal hemopoietic disorders such as myelodysplastic syndromes (MDS). Hemoglobin H acquisition, which is hemoglobin without alpha chains and with 4 beta chains is the hallmark of this disease. An 86-year-old male with chronic, microcytic anemia was referred due to a fall in his hemoglobin level. The blood smear was remarkable for intense anisocytoses and poikilocytosis. Bone marrow analysis was followed by a diagnosis of MDS with a good prognostic score. Peripheral blood coloration with brilliant cresyl blue showed "golf ball-like" erythrocytes. Hemoglobin electrophoresis is notable for the presence of H hemoglobin. The new generation sequencing confirmed the diagnosis of ATMDS showing a non-sense mutation in the gene ATRX. The diagnosis of ATMDS should be considered in the presence of the association of MDS, microcytic anemia and marked blood smear abnormalities such as anisocytosis and poikilocytosis. A little less than 10% of all MDS are complicated by ATMDS. Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

Citation

D Cortese, C Martinez, A Dindoyal, I Alamome, R Dragan, J Chapiro, G Blaison, O Hinschberger. Acquired alpha-thalassemia in an 86-year-old patient with myelodysplastic syndrome]. La Revue de medecine interne. 2023 Feb;44(2):89-91