Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro.

Esterase D (ESD) is a nonspecific esterase widely distributed in various organisms. ESD plays an important role in regulating cholesterol efflux, inhibiting viral replication and lung cancer growth. MT2A (metallothionein 2A) is the most important isoform of metallothionein (MTs) in human and high expression of MT2A in tumors represents poor prognosis and metastatic behavior. However, there are no reports about the molecular mechanism of ESD in the regulation of tumor metastasis. In this study, we found for the first time that activation ESD promoted its interaction with MT2A and decreased the protein level of MT2A, which resulting in the concentration of free zinc ions up-regulated, and inhibited the migration of A549 lung cancer cells in vitro. © 2023 Wiley Periodicals LLC.

Citation

Wen Yao, Xinpeng Chen, Xiaoling Cui, Bangzhao Zhou, Baoxiang Zhao, ZhaoMin Lin, Junying Miao. Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro. Journal of cellular biochemistry. 2023 Mar;124(3):373-381

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PMID: 36649442

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