Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis.

Shuo Yang, Long Wang, Yuesong Wu, Anguo Wu, Feihong Huang, Xiaoqin Tang, Fahsai Kantawong, Songyot Anuchapreeda, Dalian Qin, Qibing Mei, Jianping Chen, Xinwu Huang, Chunxiang Zhang, Jianming Wu

Frontiers in immunology 2022

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Platelets, generated from precursor megakaryocytes (MKs), are central mediators of hemostasis and thrombosis. The process of thrombopoiesis is extremely complex, regulated by multiple factors, and related to many cellular events including apoptosis. However, the role of apoptosis in thrombopoiesis has been controversial for many years. Some researchers believe that apoptosis is an ally of thrombopoiesis and platelets production is apoptosis-dependent, while others have suggested that apoptosis is dispensable for thrombopoiesis, and is even inhibited during this process. In this review, we will focus on this conflict, discuss the relationship between megakaryocytopoiesis, thrombopoiesis and apoptosis. In addition, we also consider why such a vast number of studies draw opposite conclusions of the role of apoptosis in thrombopoiesis, and try to figure out the truth behind the mystery. This review provides more comprehensive insights into the relationship between megakaryocytopoiesis, thrombopoiesis, and apoptosis and finds some clues for the possible pathological mechanisms of platelet disorders caused by abnormal apoptosis. Copyright © 2023 Yang, Wang, Wu, Wu, Huang, Tang, Kantawong, Anuchapreeda, Qin, Mei, Chen, Huang, Zhang and Wu.

Citation

Shuo Yang, Long Wang, Yuesong Wu, Anguo Wu, Feihong Huang, Xiaoqin Tang, Fahsai Kantawong, Songyot Anuchapreeda, Dalian Qin, Qibing Mei, Jianping Chen, Xinwu Huang, Chunxiang Zhang, Jianming Wu. Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis. Frontiers in immunology. 2022;13:1025945