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Cardiolipins are phospholipids that are central to proper mitochondrial functioning. Because mitochondria play crucial roles in differentiation, development, and maturation, we would also expect cardiolipin to play major roles in these processes. Indeed, cardiolipin has been implicated in the mechanism of three human diseases that affect young infants, implying developmental abnormalities. In this review, we will: (1) Review the biology of cardiolipin; (2) Outline the evidence for essential roles of cardiolipin during organismal development, including embryogenesis and cell maturation in vertebrate organisms; (3) Place the role(s) of cardiolipin during embryogenesis within the larger context of the roles of mitochondria in development; and (4) Suggest avenues for future research. © 2023 American Association for Anatomy.


Melissa Olivar-Villanueva, Mindong Ren, Michael Schlame, Colin K L Phoon. The critical role of cardiolipin in metazoan differentiation, development, and maturation. Developmental dynamics : an official publication of the American Association of Anatomists. 2023 Jun;252(6):691-712

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PMID: 36692477

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