Daptomycin-induced rhabdomyolysis complicated with acute gouty arthritis.

Mahmoud Abdelnabi, Natnicha Leelaviwat, En-Dien Liao, Sheedeh Motamedi, Watsachon Pangkanon, Kenneth Nugent

The American journal of the medical sciences 2023 May

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Rhabdomyolysis is a well-documented side effect of daptomycin and is associated with hyperuricemia. However, the occurrence of acute gouty arthritis secondary to rhabdomyolysis-induced hyperuricemia has not been reported. We report a case of a patient who presented with daptomycin-induced rhabdomyolysis prior to the usual 7-10-day administration period. This case was complicated with acute gouty arthritis after 7 days from the onset of rhabdomyolysis symptoms. Treatment consisted of fluid management with the addition of prednisone for gouty arthritis treatment given his poor kidney function. This report indicates the importance of early monitoring of creatine kinase levels in patients on daptomycin to prevent complications from rhabdomyolysis. Copyright © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Citation

Mahmoud Abdelnabi, Natnicha Leelaviwat, En-Dien Liao, Sheedeh Motamedi, Watsachon Pangkanon, Kenneth Nugent. Daptomycin-induced rhabdomyolysis complicated with acute gouty arthritis. The American journal of the medical sciences. 2023 May;365(5):450-456