Rewiring of metabolic pathways in yeasts for sustainable production of biofuels.

Bioresource technology 2023 Mar

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The ever-increasing global energy demand has led world towards negative repercussions such as depletion of fossil fuels, pollution, global warming and climate change. Designing microbial cell factories for the sustainable production of biofuels is therefore an active area of research. Different yeast cells have been successfully engineered using synthetic biology and metabolic engineering approaches for the production of various biofuels. In the present article, recent advancements in genetic engineering strategies for production of bioalcohols, isoprenoid-based biofuels and biodiesels in different yeast chassis designs are reviewed, along with challenges that must be overcome for efficient and high titre production of biofuels. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Rupesh Maurya, Nisarg Gohil, Snovia Nixon, Nilesh Kumar, Santosh B Noronha, Debarun Dhali, Heykel Trabelsi, Khalid J Alzahrani, Shamlan M S Reshamwala, Mukesh Kumar Awasthi, Suresh Ramakrishna, Vijai Singh. Rewiring of metabolic pathways in yeasts for sustainable production of biofuels. Bioresource technology. 2023 Mar;372:128668